This drug belongs to the group of antidiabetics immunobiological insulin preparations, analogues of human insulin, designed to reduce blood sugar levels, prolonged action.
This hypoglycemic effect of this drug is due to the ability of glucose to be more actively absorbed by the tissues of the body after the binding of insulin released into the blood and the receptors of muscle cells and lipids. At the same time, the secretion of glucose by liver cells is inhibited.
As shown by clinical studies, the use of insulin by intravenous administration reduced the number of deaths by 42% when normalizing blood sugar levels (glycemia levels) (normoglycemia phenomenon). The effect of the drug lasts for 24 hours. It also produces anti-catabolic and anabolic effects, producing a multifaceted effect on metabolic processes in all tissues of the body.
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Composition and release form
The main active ingredient: insulin glargine (rDNA). Auxiliary components: metacresol, zinc chloride, glycerin, sodium hydroxide, hydrochloric acid, water for injection. It is produced in the form of a solution for injection, in cartridges of 3 ml, 100U in 1 ml.
This drug is used in the treatment of diabetes, to maintain normal blood sugar levels.
Consider the drug is contraindicated to apply in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.
Not used with low blood sugar (hypoglycemia). Do not use before 2 years of age.
Use during pregnancy and lactation
This drug, if necessary, is used in the treatment of pregnant women, as well as nursing mothers.
It should be borne in mind that the need for insulin usually decreases in the first trimester of pregnancy and increases significantly in the second and third trimesters. After the baby is born, the level of need for blood sugar returns.
Lantus dosage and administration
The daily human need for insulin depends on the neglect of the disease, body weight, age, diet, physical exertion, the degree of insulin resistance and the dynamics of the glycemia level.
Therefore, the dosage is strictly individual and can vary and be adjusted depending on the level of sugar in the blood, physical activity, the amount of carbohydrates consumed, infectious and other diseases, based on the fact that the average daily requirement is in the range from 0.5 to 1 IU per kg of weight per day. With obesity, pregnancy and the presence of insulin resistance, the need for insulin increases.
Insulin is injected 30 minutes before a meal. It is injected subcutaneously (into the skin on the thigh, buttocks, shoulder, abdomen). After injection, the needle remains under the skin for another 6 seconds, which contributes to the introduction of a full dose.
Periodic change of the injection site reduces lipodystrophy. It is strictly forbidden to administer the drug intravenously.
An overdose may cause a sharp drop in the level of sugar in the blood, which threatens with loss of consciousness, coma and death.
When approaching a hypoglycemic attack, take a short carbohydrate as quickly as possible – the best sugar. When sugar is diluted in a liquid in high concentration, its entry into the blood will be most effective.
When unconsciousness and inability to consume carbohydrates orally is recommended, subcutaneous or intramuscular administration of glucagon (0.5-1 mg) is recommended.
When there is a mortal danger, if within 15 minutes the patient does not respond to the administration of glucagon, glucose is administered intravenously (only a doctor!)
After the patient regained consciousness, he is given to take foods with a high glycemic index.
Lantus side effects
The most common side effect of insulin administration is hypoglycemia.
Also can be observed:
- violations of refraction, swelling of the reaction at the injection site (pain, redness, urticaria, inflammation, bruising, swelling, itching at the injection site) – are usually observed at the beginning of treatment;
- temporary exacerbation of diabetic retinopathy (long-term glycemic control reduces the risk of progression of diabetic retinopathy);
- anaphylactic reactions, peripheral neuropathies (painful neuropathies);
- refractive disorders, diabetic retinopathy;
Terms and conditions of storage
Shelf life – up to 3 years. Storage temperature should not be lower than 2 or exceed 8°C. Do not freeze! After the first opening, it is valid for up to 4 weeks, at a storage temperature not higher than 25°C.